Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.

Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

beauty
cleaning
food
industrial

Papain

CAS 9001-09-6 · 40/100 · High conf.

Also registered as 6 other CAS numbers

8050-04-2 · 8057-83-8 · 9002-59-9 · 9086-65-1 · 125054-90-2 · 9001-73-4

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Papain in plain language

What it is: Also known as E-1101(II) · Ins NO.1101(II) · INS-1101(II) · Papayotin · Adolph's Meat Tenderizer · Collupulin
Show all 14 names
E.c. 3.4.22.2 · E.c. 3.4.4.10 · Fermizyme V 100 · Liquipanol · Liquipanol T-200 · Nematolyt · Papain (carica papaya l.) · papaine
What it does: Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.
Skin conditioning
Hair conditioning
Antistatic
Enzyme preparation
Thickener
Conditioner
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 185 composition records across product categories including Food and drug, Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Papain appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUCosIngActivePapain
- PapainSource →
GLOBALJECFANOT LIMITEDJECFA evaluation lists ADI NOT LIMITED. Functional class: enzyme preparation.
- JECFA evaluation lists ADI NOT LIMITED. Functional class: enzyme preparation.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 185 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Chemical reaction regulator.
- EPA CPDat observed this chemical in 185 composition records across product categories including Food and drug, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, Chemical reaction regulator.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 3 active drug products and 3 total products.
- FDA NDC lists this ingredient in 3 active drug products and 3 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
- openFDA substance registry classifies this ingredient as protein.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI NOT LIMITED. Functional class: enzyme preparation.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Papain yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated September 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Papain in a product composition. These are source records, not Greenveil catalog products.

Source records

185

Named organisations

Food and drugLaboratory suppliesPersonal care

Typical roles

Skin conditioningHair conditioningAntistaticEnzyme preparationThickenerConditioner

See products using Papain →

Catalog

Found in these products

Their ingredient lists include Papain; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 270 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Papain in the catalog.