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  • beauty
  • cleaning

Chlorhexidine dihydrochloride

CAS 3697-42-5

Chlorhexidine dihydrochloride chemical structure

Concern score

Not assessed — no hazard data yet.

Chlorhexidine dihydrochloride in plain language

What it is

Also known as Chlorhexidine hydrochloride · Chlorhexidine hcl · AY-5312 · Arlacide H · Chlorhexidin . 2 hcl · Chlorhexidindihydrochlorid

Show all 8 names

Dantroche hibitane · chlorhexidini hydrochloridum

What it does

Used in cosmetics as a preservative, an antimicrobial and an oral-care ingredient. Chlorhexidine Dihydrochloride is a salt of Chlorhexidine and hydrochloric acid.

  • Preservative
  • Antimicrobial
  • Oral care
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Chlorhexidine dihydrochloride appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • EUCosIngActiveChlorhexidine Dihydrochloride is a salt of Chlorhexidine and hydrochloric acid. It conforms generally to the formula: Restriction: V/42
    • Chlorhexidine Dihydrochloride is a salt of Chlorhexidine and hydrochloric acid. It conforms generally to the formula: Restriction: V/42Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 590 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative, oral care.
    • EPA CPDat observed this chemical in 590 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Biocide, Preservative, oral care.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Chlorhexidine dihydrochloride. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Chlorhexidine dihydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated September 2013

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Chlorhexidine dihydrochloride in a product composition. These are source records, not Greenveil catalog products.

Source records

590

Named organisations

6

Personal care

Typical roles

PreservativeAntimicrobialOral care
See products using Chlorhexidine dihydrochloride →

Catalog

Found in these products

Cosmetic and personal-care products that list Chlorhexidine dihydrochloride are shown first. Their ingredient lists include Chlorhexidine dihydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.