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  • beauty
  • industrial

18-Crown-6

CAS 63172-42-9

Also registered as 11 other CAS numbers

65154-22-5 · 66037-87-4 · 71210-94-1 · 71211-03-5 · 71245-01-7 · 71251-38-2 · 71251-39-3 · 71251-42-8 · 134316-24-8 · 168081-58-1 · 17455-13-9

18-Crown-6 chemical structure

Concern score

Not assessed — no hazard data yet.

18-Crown-6 in plain language

What it is

On cosmetic ingredient lists it appears as “Cyclo PEG-6”.

Also known as Cyclo PEG-6 · 1,4,7,10,13,16-Hexaoxacyclooctadecane · 18-CROWN ETHER-6 · Ethylene oxide cyclic hexamer · 1,4,7,10,13,16-Hexanoxacyclooctadecane · 1,4,7,10,13,16-Hexaoxacyclooctadecan

Show all 13 names

1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6) · 1,4,7,10,13,16-hexaoxaciclooctadecano · 18-Crown-6 ether · 18-crown6 · Crown ETHER/18-CROWN-6 · Hexaoxacyclooctadecane · UNII-63J177NC5B

What it does

We don't have a plain-language description for 18-Crown-6 yet.

Recorded functional uses: Not reported · No specific technical function

Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. 18-Crown-6 appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 3 composition records across product categories including Laboratory supplies, Raw materials. EPA CPDat classifies this chemical for functional uses including No specific technical function.
    • EPA CPDat observed this chemical in 3 composition records across product categories including Laboratory supplies, Raw materials. EPA CPDat classifies this chemical for functional uses including No specific technical function.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 18-Crown-6. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 18-Crown-6 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2019-12-20

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed 18-Crown-6 in a product composition. These are source records, not Greenveil catalog products.

Source records

3

Named organisations

2

Laboratory suppliesRaw materials

Typical roles

Not reportedNo specific technical function
See products using 18-Crown-6 →