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  • industrial

Apocynin

CAS 16522-48-8

Also registered as 1 other CAS number

498-02-2

Apocynin chemical structure

Concern score

Not assessed — no hazard data yet.

Apocynin in plain language

What it is

Also known as Acetovanillone · 1-(4-Hydroxy-3-methoxyphenyl)ethan-1-one · 1-(4-hydroxy-3-methoxyphenyl)ethanone · 4-HYDROXY-3-METHOXYACETOPHENONE · 1-(4-hydroxy-3-methoxy- phenyl)-ethanone · 2-Methoxy-4-acetylphenol

Show all 20 names

3'-Methoxy-4'-hydroxyacetophenone · 3-Methoxy-4-hydroxyacetophenone · 4'-HYDROXY-3'-METHOXY acetophenone · 4'-Hydroxy-3'-methoxyacetophenone · 4'-hidroxi-3'-metoxiacetofenona · 4-Acetyl-2-methoxyphenol · 4-Acetylguaiacol · 4-Hydroxy-3-methoxyphenyl methyl ketone · Acetoguaiacon · Acetoguaiacone · Acetovanilone · Acetovanyllon · Apocynine · Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Fragrance
  • Flavouring
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Apocynin appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveApocynin is the organic compound that conforms to the formula:
    • Apocynin is the organic compound that conforms to the formula:Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient, Fragrance.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient, Fragrance.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Apocynin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Apocynin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2022-06-22

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Apocynin in a product composition. These are source records, not Greenveil catalog products.

Named organisations

5

Typical roles

Skin conditioningFragranceFlavouring
See products using Apocynin →