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Silsesquioxanes, Me

CAS 149316-68-7 · 20/100 · High conf.

Also registered as 8 other CAS numbers

183598-92-7 · 189303-17-1 · 478007-70-4 · 585533-67-1 · 701949-38-4 · 1454659-19-8 · 2402790-45-6 · 68554-70-1

Concern score

20/100Minor concern based on regulatory listings.
High confidence

Silsesquioxanes, Me in plain language

What it is

On cosmetic ingredient lists it appears as “Polymethylsilsesquioxane”.

Also known as Polymethylsilsesquioxane · Methylsilsesquioxane · Polymethylsilsesquioxane (4.5 microns) · Diasphere ks 200C · Fluoropure 100C · Tospearl 145A

Show all 12 names

Msp-m · Msp-s · Methyl silsesquioxanes · Plos-m · Tospearl 130 · Xc 99A3849

What it does

Used in cosmetics as an opacifier. Polymer formed by hydrolysis and condensation of methyltrimethoxysilane.

  • Opacifying
  • Opacifier
Is it a concern?
Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 1186 composition records across product categories including Personal care, Construction, Arts and crafts/office supplies.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Silsesquioxanes, Me appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • EUCosIngActivePolymer formed by hydrolysis and condensation of methyltrimethoxysilane
    • Polymer formed by hydrolysis and condensation of methyltrimethoxysilaneSource →
  • EUEFSAEFSA opinionOpinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a 4th list of substances for food contact materials (EFSA AFC)
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a 4th list of substances for food contact materials (EFSA AFC)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1186 composition records across product categories including Personal care, Construction, Arts and crafts/office supplies. EPA CPDat classifies this chemical for functional uses including Opacifer.
    • EPA CPDat observed this chemical in 1186 composition records across product categories including Personal care, Construction, Arts and crafts/office supplies. EPA CPDat classifies this chemical for functional uses including Opacifer.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as polymer.
    • openFDA substance registry classifies this ingredient as polymer.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to a 4th list of substances for food contact materials (EFSA AFC)

      2004 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Silsesquioxanes, Me yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (1)
Openfda substance

koboproductsinc.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Silsesquioxanes, Me in a product composition. These are source records, not Greenveil catalog products.

Source records

1,186

Named organisations

6

Personal careConstructionArts and crafts/office suppliesBatteries

Typical roles

OpacifyingOpacifier
See products using Silsesquioxanes, Me →

Catalog

Found in these products

Their ingredient lists include Silsesquioxanes, Me; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 109 →Find products without it →