- beauty
- pharma
Bilirubin
CAS 18422-02-1
Also registered as 11 other CAS numbers
93891-87-3 · 114-24-9 · 493-86-7 · 917-01-1 · 11053-42-2 · 19245-52-4 · 39372-61-7 · 55527-40-7 · 856927-39-4 · 1076199-07-9 · 635-65-4
Concern score
Not assessed — no hazard data yet.
Bilirubin in plain language
Also known as Bilirubin test · (4Z,15Z)-BILIRUBIN ix.alpha. · Bilirubin ix.alpha. · Cholerythrin · Hematoidin · (4Z,15Z)-Bilirubin IXα
Show all 19 names
(Z,Z)-Bilirubin · (Z,Z)-Bilirubin IXα · Bilirubin IXalpha · Bilirubin IXα · Calcium Bilirubinate · Bilirubine · Calcium Salt Bilirubin · Disodium Salt Bilirubin · Hemetoidin · Monosodium Salt Bilirubin · bilirubin/bile pigment/hematoidine · bilirubina · delta Bilirubin
Used in cosmetics as an antioxidant, a chelating agent and a reducing agent. Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates.
- Antioxidant
- Chelating
- Reducing
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
Regulation
No restrictions found. Bilirubin appears in these published regulatory listings.
- In marketed US drugs
- Found in consumer products
- Beauty
EUCosIngActiveBilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula
- Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formulaSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 1 composition records across product categories including Personal care.
- EPA CPDat observed this chemical in 1 composition records across product categories including Personal care.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 3 total products.
- FDA NDC lists this ingredient in 2 active drug products and 3 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Bilirubin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Bilirubin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EPA Chemical and Products Database
exposure · updated 2019-02-27
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA National Drug Code Directory
regulatory · updated 2029-10-17
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often FDA National Drug Code directory has listed Bilirubin in a product composition. These are source records, not Greenveil catalog products.
Source records
3
Typical roles
AntioxidantChelatingReducing