# BILIRUBIN

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid8060905
Categories: beauty, pharma
Functions: Antioxidant, Chelating, Reducing
Identifier: DTXSID8060905

> BILIRUBIN: Used in cosmetics as an antioxidant, a chelating agent and a reducing agent. Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates. EPA CPDat observed this chemical in 1 composition records across product categories including Personal care. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 1 composition records across product categories including Personal care.

## Regulatory status

- EU: Active — Bilirubin is a red-orange colored metabolite formed during the breakdown of hemoglobin in vertebrates that conforms to the formula
- US: commercial use observed — EPA CPDat observed this chemical in 1 composition records across product categories including Personal care.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 2 active drug products and 3 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/104326
- EPA Chemical and Products Database (updated 2019-02-27): http://siri.org/msds/f2/bwz/bwzsn.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA National Drug Code Directory (updated 2029-10-17): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:RFM9X3LJ49
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/5280352

_Assessed by Greenveil._