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L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

CAS 64519-44-4

Also registered as 1 other CAS number

68127-22-0

L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester chemical structure

Concern score

Not assessed — no hazard data yet.

L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester in plain language

What it is

On cosmetic ingredient lists it appears as “Menthyl PCA”.

Also known as Menthyl PCA · Menthyl pyrrolidone carboxylate, l-(-)- · (-)-menthyl l-pidolate · (-)-menthyl l-pyroglutamate · (-)-menthyl l-pyrrolidone carboxylate · Menthyl pyroglutamate, (-),l-

Show all 10 names

Menthyl pyrrolidone carboxylate, (-)- · (-)-Menthyl (-)-2-pyrrolidone-5-carboxylate · Menthyl pyrrolidone carboxylate, (-),L- · UNII-C7ZIB25BE7

What it does

Used in cosmetics as a humectant and a skin-conditioning agent.

  • Humectant
  • Skin conditioning
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

What we know about this ingredient

EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.

Regulation

No restrictions found. L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester appears in these published regulatory listings.

  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Catalog

Found in these products

Cosmetic and personal-care products that list L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester are shown first. Their ingredient lists include L-Proline, 5-oxo-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; each product's own rating depends on its whole formula, so it is shown on the product page, not here.