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Oestrogens

CAS 12126-59-9 · 100/100 · High conf.

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Oestrogens in plain language

What it is

On cosmetic ingredient lists it appears as “Diosgenin”.

Also known as Diosgenin · Diosmetin · Estradiol · Estratetraenol · Ethinylestradiol · Conjugated estrogens

Show all 19 names

Estrogens conjugated · Estrogen, conjugated (class) · Amnestrogen · CO-Estro · Climestrone · Conestron · Conjugated equine estrogen · estrogens Conjugates · G03CA57 · Premarin · Conjugated prempro component estrogens · Premphase component conjugated estrogens · Prempro component conjugated estrogens

What it does

We don't have a plain-language description for Oestrogens yet.

Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Oestrogens is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Pharma
  • Food
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActiveCosmetics Regulation annex II / ref 260.
    • Cosmetics Regulation annex II / ref 260.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1 composition records across product categories including Food and drug.
    • EPA CPDat observed this chemical in 1 composition records across product categories including Food and drug.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 29 active drug products and 29 total products.
    • FDA NDC lists this ingredient in 29 active drug products and 29 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
    • openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

No expert opinion on file for Oestrogens. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Oestrogens yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-15

    Open →
  • EPA Chemical and Products Database

    exposure · updated March 8, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Oestrogens in a product composition. These are source records, not Greenveil catalog products.

Source records

29

See products using Oestrogens →