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Sodium bicarbonate

E500 · CAS 151127-72-9 · 40/100 · High conf.

Also registered as 11 other CAS numbers

172672-17-2 · 196216-68-9 · 199723-76-7 · 246180-97-2 · 276253-15-7 · 1182403-48-0 · 1262770-77-3 · 1809080-94-1 · 2640375-95-5 · 2755085-23-3 · 144-55-8

Sodium bicarbonate chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Sodium bicarbonate in plain language

What it is

Also known as Sodium hydrogen carbonate · Baking soda · Bicarbonate of soda · Carbonic acid monosodium salt · Carbonic acid sodium salt (1:1) · Genitron tp-bch 51051

Show all 43 names

Hydrocerol esc 5671 · Nabic · Sodium acid carbonate · Sodium bicarbonate anhydrous · Armex Blast Media Flow Formula XL · Bakeshure 180 · Bakeshure 195 · Bicar Tec · Cellborn FE 507 · Col-evac · E-500(II) · Ins NO.500(II) · INS-500(II) · Jusonin · Monosodium carbonate · Meylon · Monosodium hydrogen carbonate · NaHCO3 · Natrii hydrogencarbonas · Natrium bicarbonicum · Natriumhydrogenkarbonat · Neut · Sel De vichy · Soda Mint · Sodium hydrogencarbonate · Soludal · sodium bicarbonate (1:1) · sodium bicarbonate (5-10%) · sodium bicarbonate(5-10%) (cas #144-55-8) · sodium hydrogen carbonate or sodium bicarbonate · Baros component sodium bicarbonate · Halflytely component sodium bicarbonate · Natrum bicarbonicum · Normocarb component sodium bicarbonate · Zegerid component sodium bicarbonate · Multibic component sodium hydrogen carbonate · natrii hydrogenocarbonas

What it does

Used in cosmetics as an abrasive, a deodorant and an oral-care ingredient.

  • Abrasive
  • Deodorant
  • Oral care
  • Skin protecting
  • Buffering
  • Acidity regulator, leavening agent, raising agent
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

As a food additive

E-number
E500
Used in food as
  • Raising agent
  • Acidity regulator
  • Anti-caking agent
EU safety status

Authorised in the EU without a numerical limit (Group I); EFSA re-evaluation not yet published.

It never counts as an additive of concern in a product’s food rating.

Regulation (EC) No 1333/2008, Annex II Part C(1) Group I (quantum satis)

Why it's flagged

EPA CPDat observed this chemical in 1768 composition records across product categories including Construction and building materials, Furniture and furnishings, Laboratory supplies.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sodium bicarbonate appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database34 entries — 11 administration routes
    • Route: INTRAPERITONEAL; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: ADJ PHSource →
    • Route: INTRATHECAL; Dosage form: INJECTION; Potency: 0.05 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 812 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Maximum daily exposure: 3219 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Maximum daily exposure: 160 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 3059 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 52 mgSource →
    • Route: INTRAVITREAL; Dosage form: INJECTION; Potency: 0.18 %w/vSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 320 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 4 mgSource →
    • Route: ORAL; Dosage form: FILM, SOLUBLE; Maximum daily exposure: 2 mgSource →
    • Route: ORAL; Dosage form: GRANULE, EFFERVESCENT; Potency: 267 mgSource →
    • Route: ORAL; Dosage form: GUM, CHEWING; Maximum daily exposure: 360 mgSource →
    • Route: ORAL; Dosage form: LOZENGE; Maximum daily exposure: 100 mgSource →
    • Route: ORAL; Dosage form: POWDER, FOR SOLUTION; Potency: 1250 mg/100mlSource →
    • Route: ORAL; Dosage form: SOLUTION; Potency: ADJ PHSource →
    • Route: ORAL; Dosage form: TABLET; Potency: 1300 mgSource →
    • Route: ORAL; Dosage form: TABLET, CHEWABLE; Potency: 140 mgSource →
    • Route: ORAL; Dosage form: TABLET, COATED; Potency: 10.6 mgSource →
    • Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 30 mgSource →
    • Route: ORAL; Dosage form: TABLET, EFFERVESCENT; Maximum daily exposure: 57600 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 81 mgSource →
    • Route: ORAL; Dosage form: TABLET, FILM COATED; Maximum daily exposure: 86 mgSource →
    • Route: ORAL; Dosage form: TABLET, ORALLY DISINTEGRATING; Maximum daily exposure: 107 mgSource →
    • Route: ORAL; Dosage form: TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE; Maximum daily exposure: 6 mgSource →
    • Route: RESPIRATORY (INHALATION); Dosage form: SOLUTION; Potency: 2 %w/wSource →
    • Route: SUBCUTANEOUS; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: SUBLINGUAL; Dosage form: TABLET; Maximum daily exposure: 6 mgSource →
    • Route: VAGINAL; Dosage form: INSERT; Maximum daily exposure: 129 mgSource →
    • Route: BUCCAL; Dosage form: GUM, CHEWING; Maximum daily exposure: 240 mgSource →
    • Route: BUCCAL; Dosage form: TABLET; Maximum daily exposure: 42 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 175 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 1000 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: ADJ PHSource →
  • EUEFSAConclusion on Pesticides Peer Review2 entries
    • Peer review of the pesticide risk assessment of the active substance sodium hydrogen carbonate (EFSA)Source →
    • Conclusion on the peer review of the pesticide risk assessment of the active substance potassium hydrogen carbonate (EFSA)Source →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • GLOBALJECFANOT LIMITEDJECFA evaluation lists ADI NOT LIMITED. Functional class: acidity regulator, leavening agent, raising agent.
    • JECFA evaluation lists ADI NOT LIMITED. Functional class: acidity regulator, leavening agent, raising agent.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1768 composition records across product categories including Construction and building materials, Furniture and furnishings, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Chelating agent, Abrasive.
    • EPA CPDat observed this chemical in 1768 composition records across product categories including Construction and building materials, Furniture and furnishings, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Chelating agent, Abrasive.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 223 active drug products and 250 total products.
    • FDA NDC lists this ingredient in 223 active drug products and 250 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →
  • USUSDA FoodData Centralobserved in branded food ingredient statementsObserved in 1 USDA branded foods including 1 LITER BOTTLE VICHY WATER.
    • Observed in 1 USDA branded foods including 1 LITER BOTTLE VICHY WATER.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Peer review of the pesticide risk assessment of the active substance sodium hydrogen carbonate (EFSA)

      2018 · EU EFSA listing · Read the source →

    • Conclusion on the peer review of the pesticide risk assessment of the active substance potassium hydrogen carbonate (EFSA)

      2012 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI NOT LIMITED. Functional class: acidity regulator, leavening agent, raising agent.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Sodium bicarbonate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

11 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 28, 2015

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

  • USDA Branded Foods

    product_occurrence · updated 2026-02-19

    Open →
Reference links (2)
Openfda substance

ncbi.nlm.nih.gov

Read →
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Sodium bicarbonate in a product composition. These are source records, not Greenveil catalog products.

Source records

1,768

Named organisations

6

Construction and building materialsFurniture and furnishingsLaboratory suppliesCleaning products and household careVehicleFood and drug

Typical roles

AbrasiveDeodorantOral careSkin protectingBufferingAcidity regulator, leavening agent, raising agent
See products using Sodium bicarbonate →

Catalog

Found in these products

Their ingredient lists include Sodium bicarbonate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 364 →Find products without it →