What does Sodium pyrophosphate do?

Used in cosmetics as an oral-care ingredient, an anticaking agent and a pH buffer. Tetrasodium Pyrophosphate is the inorganic salt.

Is Sodium pyrophosphate safe?

We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

beauty
cleaning
food
industrial

Sodium pyrophosphate

CAS 1004291-85-3

Also registered as 5 other CAS numbers

93269-17-1 · 156460-73-0 · 192507-07-6 · 1269628-79-6 · 7722-88-5

Concern score

Not assessed — no hazard data yet.

Sodium pyrophosphate in plain language

What it is: On cosmetic ingredient lists it appears as “Tetrasodium pyrophosphate”.
Also known as Tetrasodium pyrophosphate · Tetrasodium diphosphate · Tetrasodium salt diphosphoric acid · tetrasodium;phosphonato phosphate · Accoline 126 · Anhydrous tetrasodium pyrophosphate
Show all 22 names
Diphosphoric acid, sodium salt (1:4) · Natriumpyrophosphat · Natrium pyrophosphat · Pp · Phosphotex · Pyrophosphate de tetrasodium · Pyrophosphoric acid tetrasodium salt · Sodium diphosphate · Sodium diphosphate (Na4P2O7) · anhydrous Sodium diphosphate · Sodium phosphate (Na4P2O7) · Sodium pyrophosphate (Na4P2O7) · tetrabasic Sodium pyrophosphate · Tspp · Victor TSPP · pirofosfato de tetrasodio
What it does: Used in cosmetics as an oral-care ingredient, an anticaking agent and a pH buffer. Tetrasodium Pyrophosphate is the inorganic salt.
Oral care
Anticaking
Buffering
Chelating
Acidity regulator, emulsifier, sequestrant
Emulsifier
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Sodium pyrophosphate appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database3 entries — 3 administration routes
- Route: DENTAL; Dosage form: PASTE, DENTIFRICE; Potency: 1 %w/wSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 12 mgSource →
- Route: BUCCAL; Dosage form: SOLUTION; Potency: NASource →
GLOBALJECFAEvaluated2 entries
- JECFA evaluation record. Functional class: acidity regulator, emulsifier, sequestrant.Source →
- JECFA evaluation record.Source →
EUCosIngActiveTetrasodium Pyrophosphate is the inorganic salt that conforms to the formula
- Tetrasodium Pyrophosphate is the inorganic salt that conforms to the formulaSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 678 composition records across product categories including Food contact items, Construction and building materials, Furniture and furnishings. EPA CPDat classifies this chemical for functional uses including Pharmaceutical, pH regulating agent, Chelating agent.
- EPA CPDat observed this chemical in 678 composition records across product categories including Food contact items, Construction and building materials, Furniture and furnishings. EPA CPDat classifies this chemical for functional uses including Pharmaceutical, pH regulating agent, Chelating agent.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 10 active drug products and 10 total products.
- FDA NDC lists this ingredient in 10 active drug products and 10 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation record. Functional class: acidity regulator, emulsifier, sequestrant.
  Year not recorded · GLOBAL JECFA listing · Read the source →
- JECFA evaluation record.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Sodium pyrophosphate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated february 8, 2013
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

chemindustry.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Sodium pyrophosphate in a product composition. These are source records, not Greenveil catalog products.

Source records

678

Named organisations

Food contact itemsConstruction and building materialsFurniture and furnishingsCleaning and safetyCleaning products and household careLaboratory supplies

Typical roles

Oral careAnticakingBufferingChelatingAcidity regulator, emulsifier, sequestrantEmulsifier

See products using Sodium pyrophosphate →

Catalog

Found in these products

Their ingredient lists include Sodium pyrophosphate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 252 →Find products without it →