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1(3H)-Isobenzofuranone, 3-butylidene-

CAS 551-08-6

Concern score

Not assessed — no hazard data yet.

1(3H)-Isobenzofuranone, 3-butylidene- in plain language

What it is

On cosmetic ingredient lists it appears as “Butylidenephthalide”.

Also known as Butylidenephthalide · 3-BUTYLIDENEPHTHALIDE · 3-BUTYLIDENEPHTHALIDE, mixture of cis and trans isomers · 3-Butylidene-2-benzofuran-1(3H)-one · Ligusticum lactone · N-butylidenephthalide, (e)+(z)

Show all 11 names

Phthalide, 3-BUTYLIDENE- · 3-Butylidene phthalide · 3-Butylidene-1(3H)-isobenzofuranone · Butylidene phthalide · n-Butylidene phthalide

What it does

Used in cosmetics as a fragrance ingredient.

  • Perfuming
  • Fragrance
  • Flavouring
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. 1(3H)-Isobenzofuranone, 3-butylidene- appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
    • openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

No expert opinion on file for 1(3H)-Isobenzofuranone, 3-butylidene-. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 1(3H)-Isobenzofuranone, 3-butylidene- yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated February 8, 2019

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed 1(3H)-Isobenzofuranone, 3-butylidene- in a product composition. These are source records, not Greenveil catalog products.

Named organisations

4

Typical roles

PerfumingFragranceFlavouring
See products using 1(3H)-Isobenzofuranone, 3-butylidene- →