- beauty
Cyclo(his-pro)
CAS 96887-26-2
Also registered as 3 other CAS numbers
102937-72-4 · 53109-32-3 · 2254826-95-2
Concern score
Not assessed — no hazard data yet.
Cyclo(his-pro) in plain language
On cosmetic ingredient lists it appears as “Imidazolylmethyl pyrrolopiperazinedione”.
Also known as Imidazolylmethyl pyrrolopiperazinedione · Cyclo(L-histidyl-L-proline) · Cyclo(l-his-l-pro) · Cyclo-(l-histidine-l-proline) inhibitor · Cyclo(histidyl-proline) · Cyclo(prolylhistidine)
Show all 12 names
Histidylproline diketopiperazine · L,L-cyclo(histidylprolyl) · L-His-L-Pro-DKP · MLS000028694 · SMR000058881 · UNII-Q10817UXVT
Used in cosmetics as a preservative, an antioxidant and a humectant.
- Preservative
- Antioxidant
- Humectant
- Skin conditioning
- Skin protecting
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
What we know about this ingredient
EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.
Regulation
No restrictions found. Cyclo(his-pro) appears in these published regulatory listings.
EUCosIngActiveImidazolylmethyl Pyrrolopiperazinedione is the organic compound that conforms to the formula
- Imidazolylmethyl Pyrrolopiperazinedione is the organic compound that conforms to the formulaSource →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Cyclo(his-pro). These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Cyclo(his-pro) yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.