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Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride

CAS 128729-28-2 · 70/100 · High conf.

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride in plain language

What it is

On cosmetic ingredient lists it appears as “Hydroxypropyl bis(n-hydroxyethyl-p-phenylenediamine) hcl”.

Also known as Hydroxypropyl bis(n-hydroxyethyl-p-phenylenediamine) hcl · Gatcalzbqpzifw-uhfffaoysa-n · Imexine OAX · Q27236897 · UNII-0K832J58E7 · hydroxypropyl bis(n-hydroxyethyl-p-phenylenediamine)

Show all 7 names

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What it does

Used in cosmetics as a hair dye.

  • Hair dyeing
  • Colourant
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Beauty

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair dye substance in oxidative hair dye products Other conditions: After mixing under oxidative conditions the maximumconcentration applied to hair must not exceed 0.4% (as tetrahydro-chloride) Conditions of use and warnings: Hair colourants can cause severe allergic reactions Read and follow instructions

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 50 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Dye.
    • EPA CPDat observed this chemical in 50 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Dye.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

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  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2013-07-25

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2013

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride in a product composition. These are source records, not Greenveil catalog products.

Source records

50

Named organisations

5

Personal care

Typical roles

Hair dyeingColourant
See products using Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride →

Catalog

Found in these products

Cosmetic and personal-care products that list Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride are shown first. Their ingredient lists include Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) hydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 6 →Find products without it →