# ESCHERICHIA COLI EXTRACT/SH-POLYPEPTIDE-138

URL: https://app.greenveil.ai/ingredients/ingredient_inci_escherichia_coli_extract_sh_polypeptide_138
Categories: beauty
Functions: Hair conditioning, Hair waving or straightening, Surface modifier
Identifier: ESCHERICHIA COLI EXTRACT/SH-POLYPEPTIDE-138

> ESCHERICHIA COLI EXTRACT/SH-POLYPEPTIDE-138: Used in cosmetics as a hair conditioner, a hair waving or straightening agent and a surface modifier. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — Escherichia Coli Extract/sh-Polypeptide-138 is a single chain recombinant peptide produced by fermentation in E. coli, where the final product contains proteins from the E. coli host. The starting gene, which is a synthesized copy of the human gene that codes for Type II Cuticular Hb5 Keratin, is used as such or adapted to the production host. The parent protein contains a maximum of 507 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/102054

_Assessed by Greenveil._