# METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3

URL: https://app.greenveil.ai/ingredients/ingredient_inci_methionyl_hexapeptide_40_sh_decapeptide_1_tripeptide_44_rh_polypeptide_3
Categories: beauty
Functions: Skin conditioning
Identifier: METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3

> METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-POLYPEPTIDE-3: Used in cosmetics as a skin-conditioning agent. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — Methionyl Hexapeptide-40 sh-Decapeptide-1 Tripeptide-44 rh-Polypeptide-3 is a single chain recombinant fusion peptide, produced by fermentation in  E. coli.  The starting gene is synthesized by the fusion of the gene from Hexapeptide-40, sh-Decapeptide-1, Tripeptide-44 and rh-Polypeptide-3  with the initiation code for methionine. The fusion peptide contains 183 amino acids and consists of the proper sequence of the 20 standard amino acids. Restriction: II/416

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/93319

_Assessed by Greenveil._