# R-(METHIONYL SH-POLYPEPTIDE-58 DECAPEPTIDE-40)

URL: https://app.greenveil.ai/ingredients/ingredient_inci_r_methionyl_sh_polypeptide_58_decapeptide_40
Categories: beauty
Functions: Humectant, Emollient, Skin conditioning
Identifier: R-(METHIONYL SH-POLYPEPTIDE-58 DECAPEPTIDE-40)

> R-(METHIONYL SH-POLYPEPTIDE-58 DECAPEPTIDE-40): Used in cosmetics as a humectant, an emollient and a skin-conditioning agent. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — r-(Methionyl sh-Polypeptide-58 Decapeptide-40) is a single chain recombinant peptide, produced by fermentation in E. coli. The starting gene is synthesized by the fusion of the genes from sh-Polypeptide-58 and Decapeptide-40 with the initiation code for methionine. The fusion peptide contains 195 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/98411

_Assessed by Greenveil._