# R-(TETRAPEPTIDE-69 SH-POLYPEPTIDE-126 HEXAPEPTIDE-40)

URL: https://app.greenveil.ai/ingredients/ingredient_inci_r_tetrapeptide_69_sh_polypeptide_126_hexapeptide_40
Categories: beauty
Functions: Skin conditioning, Skin protecting
Identifier: R-(TETRAPEPTIDE-69 SH-POLYPEPTIDE-126 HEXAPEPTIDE-40)

> R-(TETRAPEPTIDE-69 SH-POLYPEPTIDE-126 HEXAPEPTIDE-40): Used in cosmetics as a skin-conditioning agent and a skin protectant. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — r-(Tetrapeptide-69 sh-Polypeptide-126 Hexapeptide-40) is a single chain recombinant peptide, produced by fermentation in E. coli. The starting gene is synthesized by the fusion of the genes from Tetrapeptide-69, sh-Polypeptide-126 and Hexapeptide-40. The fusion peptide contains 355 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/98416

_Assessed by Greenveil._