# RH-POLYPEPTIDE-20

URL: https://app.greenveil.ai/ingredients/ingredient_inci_rh_polypeptide_20
Categories: beauty
Functions: Skin conditioning
Identifier: RH-POLYPEPTIDE-20

> RH-POLYPEPTIDE-20: Used in cosmetics as a skin-conditioning agent. Canonical ingredient record built from 4 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 4 public-source records.

## Regulatory status

- EU: Active — rh-Polypeptide-20 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for C-C Motif Chemokine 25 used as such or adapted to the production host. It contains a maximum of 150 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416
- EU: Active — sh-Oligopeptide-20 SP is a single chain human peptide produced synthetically to be identical to a portion of the protein, C-C Motif Chemokine 25, and contains 21 amino acids consisting of alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, proline, threonine, tryptophan and tyrosine. The parent protein contains a maximum of 150 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.
- EU: Active — sh-Oligopeptide-21 SP is a single chain human peptide produced synthetically to be identical to a portion of the protein, C-C Motif Chemokine 25, and contains 21 amino acids consisting of alanine, arginine, asparagine, cysteine, glutamic acid, glutamine, glycine, isoleucine, leucine, phenylalanine, proline, serine, threonine and tyrosine. The parent protein contains a maximum of 150 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.
- EU: Active — sh-Oligopeptide-22 SP is a single chain human peptide produced synthetically to be identical to a portion of the protein, C-C Motif Chemokine 25, and contains 23 amino acids consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, leucine, lysine, methionine and proline. The parent protein contains a maximum of 150 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 standard amino acids.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/95228

_Assessed by Greenveil._