# RH-POLYPEPTIDE-33

URL: https://app.greenveil.ai/ingredients/ingredient_inci_rh_polypeptide_33
Categories: beauty
Functions: Skin conditioning, Skin protecting
Identifier: RH-POLYPEPTIDE-33

> RH-POLYPEPTIDE-33: Used in cosmetics as a skin-conditioning agent and a skin protectant. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — rh-Polypeptide-33 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Tumor Necrosis Factor Alpha used as such or adapted to the production host. It contains a maximum of 233 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/90081

_Assessed by Greenveil._