# SH-POLYPEPTIDE-148

URL: https://app.greenveil.ai/ingredients/ingredient_inci_sh_polypeptide_148
Categories: beauty
Functions: not reported
Identifier: SH-POLYPEPTIDE-148

> SH-POLYPEPTIDE-148 is used as not reported. Canonical ingredient record built from 2 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 2 public-source records.

## Regulatory status

- EU: Active — sh-Polypeptide-148 is a single chain recombinant human peptide, produced by fermentation in Pichia pastoris. The starting gene which is a synthesized copy of the human gene that codes for Collagen Alpha-1 (XVII) Chain is used as such or adapted to the production host. It contains a maximum of 1497 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids (sh-Polypeptide-148 is included in the INCI database as a reference for the definition of other INCI Names, and might not be a marketed cosmetic ingredient).
- EU: Active — sh-Polypeptide-148 is a single chain recombinant human peptide, produced by fermentation in Pichia pastoris or Escherichia coli. The starting gene which is a synthesized copy of the human gene that codes for Collagen Alpha-1 (XVII) Chain is used as such or adapted to the production host. It contains a maximum of 1497 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/101648

_Assessed by Greenveil._