# SH-POLYPEPTIDE-2

URL: https://app.greenveil.ai/ingredients/ingredient_inci_sh_polypeptide_2
Categories: beauty
Functions: Skin conditioning
Identifier: SH-POLYPEPTIDE-2

> SH-POLYPEPTIDE-2: Used in cosmetics as a skin-conditioning agent. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — sh-Polypeptide-2 is a single chain recombinant human peptide, produced by fermentation in E. Coli. The starting gene is a synthesized copy of the human gene which codes for Thioredoxin used as such or adapted to the production host.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/88968

_Assessed by Greenveil._