# SH-POLYPEPTIDE-33

URL: https://app.greenveil.ai/ingredients/ingredient_inci_sh_polypeptide_33
Categories: beauty
Functions: Skin conditioning
Identifier: SH-POLYPEPTIDE-33

> SH-POLYPEPTIDE-33: Used in cosmetics as a skin-conditioning agent. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — sh-Polypeptide-33 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Tumor Necrosis Factor Alpha. It contains a maximum of 233 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/86052

_Assessed by Greenveil._