# SH-POLYPEPTIDE-58

URL: https://app.greenveil.ai/ingredients/ingredient_inci_sh_polypeptide_58
Categories: beauty
Functions: Emollient, Skin conditioning, Skin protecting
Identifier: SH-POLYPEPTIDE-58

> SH-POLYPEPTIDE-58: Used in cosmetics as an emollient, a skin-conditioning agent and a skin protectant. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — sh-Polypeptide-58 is a single chain synthetic human peptide, produced by fermentation in E.Coli. The starting gene is a synthesized copy of the human gene which codes for Tissue Inhibitor for Metalloproteinase 1 used as such or adapted to the production host. It contains a maximum of 207 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/90908

_Assessed by Greenveil._