# STEARYLDISULFIDEHEXYL SH-DNA-3 PEG-45/SH-RNA-2

URL: https://app.greenveil.ai/ingredients/ingredient_inci_stearyldisulfidehexyl_sh_dna_3_peg_45_sh_rna_2
Categories: beauty
Functions: Hair conditioning
Identifier: STEARYLDISULFIDEHEXYL SH-DNA-3 PEG-45/SH-RNA-2

> STEARYLDISULFIDEHEXYL SH-DNA-3 PEG-45/SH-RNA-2: Used in cosmetics as a hair conditioner. Canonical ingredient record built from 1 public-source records. Compiled from 1 published data source.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: Canonical ingredient record built from 1 public-source records.

## Regulatory status

- EU: Active — Stearyldisulfidehexyl sh-DNA-3 PEG-45/sh-RNA-2 is a synthetic human RNA strand conjugated with a synthetic human complementary DNA strand which is modified at the 5' end with Stearyldisulfidehexyl and at the 3' end with polyethylene glycol. The RNA is a Dickkopf-1-specific siRNA comprised of 19 ribonucleotides. The modified DNA is a complementary strand comprised of 19 deoxyribonucleotides selected from the human Dickkopf-1 mRNAs. This was developed for effective and specific degradation of mRNA coding for Dickkopf-1.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/97661

_Assessed by Greenveil._