# RH-OLIGOPEPTIDE-1

URL: https://app.greenveil.ai/ingredients/ingredient_rh_oligopeptide_1
Categories: beauty, pharma
Functions: Skin conditioning
Identifier: RH-OLIGOPEPTIDE-1

> RH-OLIGOPEPTIDE-1: Used in cosmetics as a skin-conditioning agent. FDA NDC lists this ingredient in 2 active drug products and 2 total products. Compiled from 2 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA NDC lists this ingredient in 2 active drug products and 2 total products.

## Regulatory status

- EU: Active — rh-Oligopeptide-1 is a single chain recombinant human peptide, produced by fermentation in E. coli or Pichia pastoris and contains 53 amino acids. The starting gene is directly isolated from a human cell which codes for Epidermal Growth Factor, and codes for a total of 1207 amino acids which may contain disulfide bonds and/or sugar. The protein consists of the proper sequence of standard amino acids. EGF; Epidermal Growth Factor Restriction: II/416
- US: marketed drug occurrence — FDA NDC lists this ingredient in 2 active drug products and 2 total products.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/84391
- FDA National Drug Code Directory (updated 2026-12-31): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files

_Assessed by Greenveil._