# 4,4'-Methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate [1];
2,2'-Methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate [2];
o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate [3];
Methylenediphenyl diisocyanate [4]

URL: https://app.greenveil.ai/ingredients/ingredient_source_ref_annex_ref_ii_1533
Categories: beauty
Identifier: annex_ref:II:1533

> 4,4'-Methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate [1]; 2,2'-Methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate [2]; o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate [3]; Methylenediphenyl diisocyanate [4]. Greenveil chemical-concern score: 100/100 — Critical concern driven by cmr.. Compiled from 2 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern driven by cmr.
- Confidence in this assessment: High
- Is it a concern? Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.
- Rationale: 4,4'-Methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate [1]; 2,2'-Methylenediphenyl diisocyanate; diphenylmethane-2,2'-diisocyanate [2]; o-(p-Isocyanatobenzyl)phenyl isocyanate; diphenylmethane-2,4'-diisocyanate [3]; Methylenediphenyl diisocyanate [4] is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 1533.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 2()

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/97942
- EU CosIng Cosmetics Regulation Annexes (updated 2020-07-30): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II

_Assessed by Greenveil._