# Metaflumizone (ISO);(EZ)-2'-[2-(4-cyanophenyl)-1-(α,α,α -trifluoro-m- tolyl)ethylidene]- [4-(trifluoromethoxy)phenyl] carbanilohydrazide [E-isomer ≥ 90 %, Z-isomer ≤ 10 % relative content]; [1](E)-2'-[2-(4-cyanophenyl)- 1-(α,α,α -trifluoro-m-tolyl) ethylidene]- [4-(trifluoromethoxy)phenyl]carbanilohydrazide [2]

URL: https://app.greenveil.ai/ingredients/ingredient_source_ref_annex_ref_ii_1655
Categories: beauty
Identifier: annex_ref:II:1655

> Metaflumizone (ISO);(EZ)-2'-[2-(4-cyanophenyl)-1-(α,α,α -trifluoro-m- tolyl)ethylidene]- [4-(trifluoromethoxy)phenyl] carbanilohydrazide [E-isomer ≥ 90 %, Z-isomer ≤ 10 % relative content]; [1](E)-2'-[2-(4-cyanophenyl)- 1-(α,α,α -trifluoro-m-tolyl) ethylidene]- [4-(trifluoromethoxy)phenyl]carbanilohydrazide [2]. Greenveil chemical-concern score: 100/100 — Critical concern based on regulatory listings.. Compiled from 2 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Critical concern: no hazard classifications on record. It is banned in EU cosmetics.
- Rationale: Metaflumizone (ISO);(EZ)-2'-[2-(4-cyanophenyl)-1-(α,α,α -trifluoro-m- tolyl)ethylidene]- [4-(trifluoromethoxy)phenyl] carbanilohydrazide [E-isomer ≥ 90 %, Z-isomer ≤ 10 % relative content]; [1](E)-2'-[2-(4-cyanophenyl)- 1-(α,α,α -trifluoro-m-tolyl) ethylidene]- [4-(trifluoromethoxy)phenyl]carbanilohydrazide [2] is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 1655.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/99287
- EU CosIng Cosmetics Regulation Annexes (updated 2021-06-21): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II

_Assessed by Greenveil._