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Sodium monofluorophosphate

CAS 10163-15-2 · 70/100 · High conf.

Also registered as 3 other CAS numbers

7631-97-2 · 12331-99-6 · 69794-00-9

Sodium monofluorophosphate chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

Sodium monofluorophosphate in plain language

What it is

Also known as Sodium fluorophosphate · Disodium monofluorophosphate · Disodium phosphorofluoridate · Disodium salt phosphorofluoridic acid · disodium;fluoro-dioxido-oxo-lambda5-phosphane · AGToothpaste

Show all 32 names

Barbie · Cloveden Tooth · DeCure · Disodium fluorophosphate · Extra-Strength Aim · Finefra Silver · MyntSmile · Orazen · Phoskadent Na 211 · Priyal · Regular · Rembrandt · Salivea · Sensodyne-Fluor · SmartMouth · Sodium fluorophosphate (Na2PFO3) · Sodium phosphorofluoridate · Sodium phosphorofluoridate ((NaO)2FPO) · Sodium phosphorofluoridate (Na2PO3F) · SparkleFresh · brident · purple tooth · smilecare · sodium monofluoroph osphate · sodium monofluoropho sphate · sodium monofluorophosphat e

What it does

Used in consumer products as an oral-care ingredient.

  • Oral care
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Sodium monofluorophosphate is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Beauty

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Oral products Maximum concentration: 0.15% calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0.15% Conditions of use and warnings: Contains sodium monofluorophosphate For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use only") the following labelling is obligatory: "Children of 6 years and younger: use a pea-sized amount for supervised brushing to minimise swallowing. In case of intake of…

    restricted
    View source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 24 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Pharmaceutical, oral care, Oral Care Agent.
    • EPA CPDat observed this chemical in 24 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Pharmaceutical, oral care, Oral Care Agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 158 active drug products and 162 total products.
    • FDA NDC lists this ingredient in 158 active drug products and 162 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Sodium monofluorophosphate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Sodium monofluorophosphate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2013-05-14

    Open →

  • EPA Chemical and Products Database

    exposure · updated July 2016

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-07-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Sodium monofluorophosphate in a product composition. These are source records, not Greenveil catalog products.

Source records

162

Typical roles

Oral care
See products using Sodium monofluorophosphate →

Catalog

Found in these products

Their ingredient lists include Sodium monofluorophosphate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 199 →Find products without it →