# 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72)  and its disodium salt (CI 45370)  when used as a substance in hair dye products

URL: https://app.greenveil.ai/ingredients/ingredient_source_ref_substance_id_87688
Categories: beauty
Identifier: annex_ref:II:1333

> 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products. Greenveil chemical-concern score: 100/100 — Critical concern based on regulatory listings.. Compiled from 2 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Critical concern: no hazard classifications on record. It is banned in EU cosmetics.
- Rationale: 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one; 4',5'-Dibromofluorescein; (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 1333.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/87688
- EU CosIng Cosmetics Regulation Annexes (updated 2013-05-07): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II

_Assessed by Greenveil._