# RH-POLYPEPTIDE-64

URL: https://app.greenveil.ai/ingredients/ingredient_unii_36141_clk2_y
Categories: beauty
Functions: Skin conditioning, Skin protecting
Identifier: RH-POLYPEPTIDE-64

> RH-POLYPEPTIDE-64: Used in cosmetics as a skin-conditioning agent and a skin protectant. FDA GSRS classifies this ingredient as ingredient substance protein. Compiled from 3 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA GSRS classifies this ingredient as ingredient substance protein.

## Regulatory status

- EU: Active — rh-Polypeptide-64 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Aquaporin-1 used as such or adapted to the production host. It contains a maximum of 269 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/90037
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:36141CLK2Y

_Assessed by Greenveil._