# SH-POLYPEPTIDE-55

URL: https://app.greenveil.ai/ingredients/ingredient_unii_7_mge0_hpm2_h
Categories: beauty
Functions: Skin conditioning
Identifier: SH-POLYPEPTIDE-55

> SH-POLYPEPTIDE-55: Used in cosmetics as a skin-conditioning agent. FDA GSRS classifies this ingredient as ingredient substance protein. Compiled from 3 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA GSRS classifies this ingredient as ingredient substance protein.

## Regulatory status

- EU: Active — sh-Polypeptide-55 is a single chain synthetic human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Amphiregulin used such or adapted to the production host. It contains a maximum of 252 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/88308
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:7MGE0HPM2H

_Assessed by Greenveil._