# SH-POLYPEPTIDE-3

URL: https://app.greenveil.ai/ingredients/ingredient_unii_9_yxf283_gp1
Categories: beauty
Functions: Skin conditioning
Identifier: SH-POLYPEPTIDE-3

> SH-POLYPEPTIDE-3: Used in cosmetics as a skin-conditioning agent. It is a single chain recombinant human peptide, produced by fermentation in E. Coli. The starting gene is a synthesized copy of the human gene which codes for Keratinocyte Growth Factor used as such or adapted to the production host. FDA GSRS classifies this ingredient as ingredient substance protein. Compiled from 3 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA GSRS classifies this ingredient as ingredient substance protein.

## Regulatory status

- EU: Active — It is a single chain recombinant human peptide, produced by fermentation in E. Coli. The starting gene is a synthesized copy of the human gene which codes for Keratinocyte Growth Factor used as such or adapted to the production host.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/88971
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:9YXF283GP1

_Assessed by Greenveil._