Skip to content
  • beauty

TAK-441

CAS 1186231-83-3

TAK-441 chemical structure

Concern score

Not assessed — no hazard data yet.

TAK-441 in plain language

What it is

On cosmetic ingredient lists it appears as “Phenacyl hydroxyacetylpiperidinyl methylethyltrifluoroethoxy pyrrolopyridinonecarboxamide”.

Also known as AKOS040744812 · BDBM50401323 · DA-78168 · EX-A10390 · GLXC-15773 · GTPL8200

Show all 13 names

HY-16475 · SB18887 · Smoothened Antagonist TAK-441 · TAK441 · TS-08145 · UNII-CY3QT94KWP · Zadwxqmnnvickb-uhfffaoysa-n

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

What we know about this ingredient

FDA GSRS classifies this ingredient as ingredient substance chemical.

Regulation

No restrictions found. TAK-441 appears in these published regulatory listings.

  • EUCosIngActivePhenacyl Hydroxyacetylpiperidinyl Methylethyltrifluoroethoxy Pyrrolopyridinonecarboxamide is the organic compound that conforms to the formula.
    • Phenacyl Hydroxyacetylpiperidinyl Methylethyltrifluoroethoxy Pyrrolopyridinonecarboxamide is the organic compound that conforms to the formula.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for TAK-441. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for TAK-441 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

4 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.