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Microbial collagenase

Concern score

Not assessed — no hazard data yet.

Microbial collagenase in plain language

What it is

On cosmetic ingredient lists it appears as “Vibrio alginolyticus collagenase”.

Also known as Vibrio alginolyticus collagenase

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

What we know about this ingredient

FDA GSRS classifies this ingredient as ingredient substance protein.

Regulation

No restrictions found. Microbial collagenase appears in these published regulatory listings.

  • EUCosIngActiveVibrio Alginolyticus Collagenase is a single chain recombinant protein produced by fermentation in E. coli. The starting gene is directly isolated from Vibrio Alginolyticus which codes for the enzyme, Collagenase. The protein contains a maximum of 1021 amino acids, and consists of the proper sequence of the 20 standard amino acids.
    • Vibrio Alginolyticus Collagenase is a single chain recombinant protein produced by fermentation in E. coli. The starting gene is directly isolated from Vibrio Alginolyticus which codes for the enzyme, Collagenase. The protein contains a maximum of 1021 amino acids, and consists of the proper sequence of the 20 standard amino acids.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
    • openFDA substance registry classifies this ingredient as protein.Source →

Expert safety opinions

No expert opinion on file for Microbial collagenase. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Microbial collagenase yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

3 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (1)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.