# MICROBIAL COLLAGENASE

URL: https://app.greenveil.ai/ingredients/ingredient_unii_fy14_nzh2_sf
Categories: beauty
Functions: Skin conditioning
Identifier: VIBRIO ALGINOLYTICUS COLLAGENASE

> MICROBIAL COLLAGENASE: Used in cosmetics as a skin-conditioning agent. FDA GSRS classifies this ingredient as ingredient substance protein. Compiled from 3 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA GSRS classifies this ingredient as ingredient substance protein.

## Regulatory status

- EU: Active — Vibrio Alginolyticus Collagenase is a single chain recombinant protein produced by fermentation in E. coli. The starting gene is directly isolated from Vibrio Alginolyticus which codes for the enzyme, Collagenase. The protein contains a maximum of 1021 amino acids, and consists of the proper sequence of the 20 standard amino acids.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/106183
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:FY14NZH2SF

_Assessed by Greenveil._