# SH-POLYPEPTIDE-61

URL: https://app.greenveil.ai/ingredients/ingredient_unii_gpu59_xz1_pz
Categories: beauty, industrial
Functions: Skin conditioning, Astringent, Skin protecting, Humectant, Conditioner
Identifier: SH-POLYPEPTIDE-61

> SH-POLYPEPTIDE-61: Used in cosmetics as a skin-conditioning agent, an astringent and a skin protectant. EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. Compiled from 4 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

## Regulatory status

- EU: Active — sh-Polypeptide-61 is a synthetic peptide chemically produced to be identical to the human protein or piece of human protein, Tripartite Motif-Containing Protein 72. It contains a maximum of 477 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Humectant, Astringent, Softener and conditioner.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/93677
- EPA Chemical and Products Database (updated 2019-12-20): https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=93677
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:GPU59XZ1PZ

_Assessed by Greenveil._