- beauty
RH-POLYPEPTIDE-58
CAS 140208-24-8
Concern score
Not assessed — no hazard data yet.
RH-POLYPEPTIDE-58 in plain language
Also known as Metalloproteinase INHIBITOR-1 · Collagenase inhibitor · Erythroid-potentiating activity · Fibroblast collagenase inhibitor · Metalloproteinase inhibitor 1 · TIMP-1
Show all 9 names
TIMP1 · Tissue inhibitor of metalloproteinases 1 · BF-TIMP1
Used in cosmetics as a skin-conditioning agent and a skin protectant.
- Skin conditioning
- Skin protecting
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
What we know about this ingredient
FDA GSRS classifies this ingredient as ingredient substance protein.
Regulation
No restrictions found. RH-POLYPEPTIDE-58 appears in these published regulatory listings.
EUCosIngActiverh-Polypeptide-58 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Tissue Inhibitor for Metalloproteinase 1 used as such or adapted to the production host. It contains a maximum of 207 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416
- rh-Polypeptide-58 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Tissue Inhibitor for Metalloproteinase 1 used as such or adapted to the production host. It contains a maximum of 207 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
- openFDA substance registry classifies this ingredient as protein.Source →
Expert safety opinions
No expert opinion on file for RH-POLYPEPTIDE-58. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for RH-POLYPEPTIDE-58 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.