- beauty
RH-POLYPEPTIDE-66
Concern score
Not assessed — no hazard data yet.
RH-POLYPEPTIDE-66 in plain language
Also known as Nad-dependent protein deacetylase SIRTUIN-1 · HSIR2 · HSIRT1 · Human nad-dependent protein deacetylase SIRTUIN-1 · Nad-dependent protein deacetylase SIRTUIN-1 (human) · Regulatory protein SIR2 homolog 1
Show all 9 names
SIR2-LIKE protein 1 · NAD-dependent deacetylase sirtuin 1,SIRT 1 · Sirt 1
Used in cosmetics as a skin-conditioning agent.
- Skin conditioning
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
What we know about this ingredient
FDA GSRS classifies this ingredient as ingredient substance protein.
Regulation
No restrictions found. RH-POLYPEPTIDE-66 appears in these published regulatory listings.
EUCosIngActiverh-Polypeptide-66 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Sirtuin 1 used as such or adapted to the production host. It contains a maximum of 747 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416
- rh-Polypeptide-66 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Sirtuin 1 used as such or adapted to the production host. It contains a maximum of 747 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids. Restriction: II/416Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
- openFDA substance registry classifies this ingredient as protein.Source →
Expert safety opinions
No expert opinion on file for RH-POLYPEPTIDE-66. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for RH-POLYPEPTIDE-66 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
Reference links (2)
en.wikipedia.org
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.