# PROTEINASE-ACTIVATED RECEPTOR 2

URL: https://app.greenveil.ai/ingredients/ingredient_unii_w2_l4_sl2_gwe
Categories: beauty
Functions: Antioxidant
Identifier: SH-HEXAPEPTIDE-6 SP AMIDE

> PROTEINASE-ACTIVATED RECEPTOR 2: Used in cosmetics as an antioxidant. FDA GSRS classifies this ingredient as ingredient substance protein. Compiled from 3 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: FDA GSRS classifies this ingredient as ingredient substance protein.

## Regulatory status

- EU: Active — sh-Hexapeptide-6 SP Amide is a single chain human peptide, produced synthetically to be identical to a portion of the protein Proteinase-Activated Receptor 2, and contains 6 amino acids consisting of glycine, isoleucine, leucine, lysine, serine, and valine, in which the C-terminus is an amide.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/97060
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:W2L4SL2GWE

_Assessed by Greenveil._