Titanium dioxidePossible genotoxicity (DNA/chromosomal damage) could not be ruled out; no longer considered safe as a food additive.
AspartameSweetener; classified as possibly carcinogenic, though the evidence is contested and intake-dependent.
Carboxymethyl cellulose (CMC)Synthetic emulsifier linked in animal and in-vitro studies to gut-microbiome disruption and intestinal inflammation; human evidence is emerging.
Acesulfame KSweetener; broadly assessed safe but some consumer-avoidance and limited animal-study questions.