beauty
cleaning
food
industrial

Diazolidinyl urea

CAS 78491-02-8 · 20/100 · High conf.

Concern score

20/100Minor concern based on regulatory listings.

High confidence

Diazolidinyl urea in plain language

What it is: Also known as Diazolidinylurea · Germaben II-E · diazolidnyl urea · germall ii
What it does: Used in cosmetics as a preservative. Diazolidinyl Urea is the heterocyclic substituted urea.
Preservative
Is it a concern?: Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

What the listings say

Permitted, with conditions — Diazolidinyl urea appears on published "allowed" regulatory lists rather than on a restriction list.

N-(Hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo-2,5-imidazolidinyl-4)-N'-(hydroxymethyl)urea is listed in Annex V of the EU Cosmetics Regulation (EC) 1223/2009 (preservatives allowed in cosmetic products).

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Diazolidinyl urea appears in these published regulatory listings.

In marketed US drugs
EU Annex V — permitted preservative
EU permitted preservative
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database3 entries
- Route: TOPICAL; Dosage form: CREAM; Maximum daily exposure: 29 mgSource →
- Route: TOPICAL; Dosage form: LOTION; Potency: 3 %w/wSource →
- Route: TOPICAL; Dosage form: OINTMENT; Potency: 0.1 %w/wSource →
EUCosIngActive2 entries
- Cosmetics Regulation annex V / ref 46.Source →
- Diazolidinyl Urea is the heterocyclic substituted urea that conforms to the formula: Restriction: V/46Source →
EUECallowed_listedAnnex V of EU Cosmetics Regulation (EC) 1223/2009: preservatives allowed in cosmetic products. Maximum concentration: 0.5%
- Annex V of EU Cosmetics Regulation (EC) 1223/2009: preservatives allowed in cosmetic products. Maximum concentration: 0.5%Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 2400 composition records across product categories including Industrial products, Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Preservative.
- EPA CPDat observed this chemical in 2400 composition records across product categories including Industrial products, Personal care, Food and drug. EPA CPDat classifies this chemical for functional uses including Preservative.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
- FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as mixture.
- openFDA substance registry classifies this ingredient as mixture.Source →

Expert safety opinions

No expert opinion on file for Diazolidinyl urea. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Diazolidinyl urea yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2021-08-02
Open →
EPA Chemical and Products Database
exposure · updated september 28, 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Diazolidinyl urea in a product composition. These are source records, not Greenveil catalog products.

Source records

2,400

Named organisations

Industrial productsPersonal careFood and drugRaw materialsArts and crafts/office supplies

Typical roles

Preservative

See products using Diazolidinyl urea →

Catalog

Found in these products

Their ingredient lists include Diazolidinyl urea; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 139 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Diazolidinyl urea in the catalog.