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  • beauty
  • cleaning
  • food
  • pharma

Levomenthol

CAS 2216-51-5

Also registered as 4 other CAS numbers

89-78-1 · 114376-98-6 · 95650-44-5 · 98167-53-4

Levomenthol chemical structure

Concern score

Not assessed — no hazard data yet.

Levomenthol in plain language

What it is

Also known as L-menthol · Menthol · (-)-Menthol · (1R,2S,5R)-(-)-Menthol · (-)-TRANS-P-METHAN-CIS-3-OL · (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexan-1-ol

Show all 34 names

(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol · 1R-MENTHOL · L-(-)-menthol · L-mentholum · (-)-(1R,3R,4S)-MENTHOL · (-)-menthyl alcohol · (-)-trans-p-Menthan-cis-ol · (1R,2S,5R)-2-ISOPROPYL-5-METHYLCYCLOHEXANOL · (1R,2S,5R)-2-Isopropyl-5-methylcyclohexan-1-ol · (1R,2S,5R)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANOL · (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexanol · (1alpha,2beta,5alpha)-5-methyl-2(1-methylethyl)cyclohexanol · (r)-(-)-menthol · Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2S,5R)- · D-(-)-Menthol · Levomentholum · Menthol, (1R,3R,4S)-(-)- · Minclea · NPO-11 · U.S.P. Menthol · levomentol · menthol (1.25% w/w) · menthol (l) · menthol 0.15% · menthol 0.2% · menthol 0.5% · menthol 2.6% · menthol/5-methyl-2(methylethyl) cyclohexanol

What it does

Used in consumer products as a fragrance ingredient.

  • Fragrance
Is it a concern?
We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Levomenthol appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • USFDAinactive ingredient database10 entries — 4 administration routes
    • Route: BUCCAL; Dosage form: GUM, CHEWING; Maximum daily exposure: 113 mgSource →
    • Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 15 mgSource →
    • Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 1 mgSource →
    • Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 5 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 14 mgSource →
    • Route: ORAL; Dosage form: TABLET, ORALLY DISINTEGRATING; Maximum daily exposure: 1 mgSource →
    • Route: SUBLINGUAL; Dosage form: SPRAY; Potency: 0.05 mg/1mlSource →
    • Route: TOPICAL; Dosage form: LOTION; Potency: 0.08 %w/wSource →
    • Route: TOPICAL; Dosage form: SOLUTION; Potency: 0.08 %w/vSource →
    • Route: TOPICAL; Dosage form: SPRAY; Maximum daily exposure: 2 mgSource →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 75 composition records across product categories including Personal care, Cleaning products and household care, Food and drug. EPA CPDat classifies this chemical for functional uses including Fragrance.
    • EPA CPDat observed this chemical in 75 composition records across product categories including Personal care, Cleaning products and household care, Food and drug. EPA CPDat classifies this chemical for functional uses including Fragrance.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 76 active drug products and 77 total products.
    • FDA NDC lists this ingredient in 76 active drug products and 77 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Levomenthol. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Levomenthol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • EPA Chemical and Products Database

    exposure · updated september 30, 2015

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often FDA National Drug Code directory has listed Levomenthol in a product composition. These are source records, not Greenveil catalog products.

Source records

77

Typical roles

Fragrance
See products using Levomenthol →

Catalog

Found in these products

Their ingredient lists include Levomenthol; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Levomenthol in the catalog.