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Sodium fluoride

CAS 39287-69-9 · 70/100 · High conf.

Also registered as 4 other CAS numbers

59217-75-3 · 67112-29-2 · 2018280-11-8 · 7681-49-4

Sodium fluoride chemical structure

Concern score

70/100High concern based on regulatory listings.
High confidence

Sodium fluoride in plain language

What it is

Also known as Dentalfluoro · Pergantene · Sodium fluoride (naf) · Antibulit · Apoflux · Chemifluor

Show all 31 names

Duofluorid F · Floridine · Florocid · Fluonatril · Fluoraday · Fluorident · Fluorol · Flursol · Karidium · Koreberon · Liquiflur · Neutral sodium fluoride · Ossin · Pediaflor · Sodium flouride · Sodium monofluoride · Villiaumite · Zymafluor · sodium fluoride (sara iii) · sodium fluoride (cercla) · Colgate total component sodium fluoride · Fluoride (as sodium fluoride) · Fluoride (as sodium) · Natrum fluoratum · natrii fluoridum

What it does

Used in cosmetics as an antiplaque and an oral-care ingredient.

  • Antiplaque
  • Oral care
  • Thickener
  • Antimicrobial
Is it a concern?
High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Sodium fluoride is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Pharma
  • Industrial

  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Oral products Maximum concentration: 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 % Conditions of use and warnings: Contains sodium fluoride For any toothpaste with compounds containing fluorine in a concentration of 0.1 to 0.15% calculated as F unless it is already labelled as contra-indicated for children (e.g. "for adult use only") the following labelling is obligatory: "Children of 6 years and younger: use a pea-sized amount for supervised brushing to minimise swallowing. In case of intake of fluoride from…

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 488 composition records across product categories including Laboratory supplies, Raw materials, Medical/dental. EPA CPDat classifies this chemical for functional uses including active, Pharmaceutical, oral care.
    • EPA CPDat observed this chemical in 488 composition records across product categories including Laboratory supplies, Raw materials, Medical/dental. EPA CPDat classifies this chemical for functional uses including active, Pharmaceutical, oral care.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1107 active drug products and 1141 total products.
    • FDA NDC lists this ingredient in 1107 active drug products and 1141 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Sodium fluoride. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Sodium fluoride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2013-05-14

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 11, 2014

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2031-01-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Sodium fluoride in a product composition. These are source records, not Greenveil catalog products.

Source records

1,141

Typical roles

AntiplaqueOral careThickenerAntimicrobial
See products using Sodium fluoride →

Catalog

Found in these products

Their ingredient lists include Sodium fluoride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Sodium fluoride in the catalog.