beauty
food
industrial
pharma

Theophylline

CAS 8061-56-1 · 100/100 · High conf.

Also registered as 9 other CAS numbers

49746-06-7 · 50857-74-4 · 1246816-25-0 · 46157-00-0 · 56645-32-0 · 75448-53-2 · 111079-49-3 · 1024160-72-2 · 58-55-9

Concern score

100/100Critical concern based on regulatory listings.

High confidence

Theophylline in plain language

What it is: Also known as Theophylline anhydrous · Anhydrous theophylline · Theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione · 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione · 1,3-dimethyl-7H-purine-2,6-dione · Doxophylline metabolite M3
Show all 37 names
Theophylline melting point standard · 1,3-Dimethylxanthine · 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl- · 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl- · 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione · Accurbron · Acet-theocin · Aerobin · Aerolate · Afonilm · Elixophyllin · Elixophylline · Lanophyllin · Liquophylline · Nuelin · Optiphyllin · Parkophyllin · Pseudotheophylline · Respbid · Slo-phyllin · Solosin · Theo-dur · Theocin · Theofol · Theograd · Theolair · Theophyllin · aminophylline · liquorice · theophylline (19.7 mg/ml) · theophyllinum
What it does: Used in cosmetics as a skin-conditioning agent. Theophylline is the xanthine derivative.
Skin conditioning
Humectant
Conditioner
Is it a concern?: Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

In marketed US drugs
EU Annex II — prohibited
EU prohibited in cosmetics

Recorded in these product areas

Found in consumer products
Beauty
Pharma
Food
Industrial

EUEC
Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.
banned
View source →

EUCosIngActive2 entries
- Theophylline is the xanthine derivative that conforms to the formula:Source →
- Cosmetics Regulation annex II / ref 1710.Source →
USFDAmarketed drug occurrence2 entries
- FDA NDC lists this ingredient in 6 active drug products and 6 total products.Source →
- FDA NDC lists this ingredient in 49 active drug products and 49 total products.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 28 composition records across product categories including Personal care, Raw materials, Food and drug. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Pharmaceutical.
- EPA CPDat observed this chemical in 28 composition records across product categories including Personal care, Raw materials, Food and drug. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Pharmaceutical.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Theophylline. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Theophylline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2023-08-24
Open →
EPA Chemical and Products Database
exposure · updated November 2007
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2026-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

dailymed.nlm.nih.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Theophylline in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Personal careRaw materialsFood and drug

Typical roles

Skin conditioningHumectantConditioner

See products using Theophylline →

Catalog

Found in these products

Their ingredient lists include Theophylline; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →