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Glucosamine hydrochloride

CAS 2002-25-7 · 40/100 · High conf.

Also registered as 13 other CAS numbers

3615-52-9 · 34673-29-5 · 66573-21-5 · 151799-45-0 · 214046-22-7 · 581076-92-8 · 619328-18-6 · 885318-70-7 · 1029131-60-9 · 1334320-70-5 · 2378838-02-7 · 2411172-99-9 · 66-84-2

Glucosamine hydrochloride chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Glucosamine hydrochloride in plain language

What it is

On cosmetic ingredient lists it appears as “Glucosamine hcl”.

Also known as Glucosamine hcl · 2-Amino-2-deoxy-D-glucopyranose--hydrogen chloride (1/1) · Chitosamine hydrochloride · D-glucosamine hydrochloride · 2-Amino-2-deoxy-D-glucose hydrochloride · 2-Amino-D-glucose

Show all 16 names

2-Deoxy-2-amino-D-glucose hydrochloride · Artrox (TN) · Cosamin · D-(+)-Glucosamine hydrochloride · D-glucose, 2-AMINO-2-DEOXY-, hydrochloride (1:1) · D-Glucosamine chloride · D-Glucosamine monohydrochloride · D-Glucose, 2-amino-2-deoxy-, hydrochloride · UNII-750W5330FY · Glucosamine (as hydrochloride)

What it does

Used in cosmetics as a hair conditioner and an antistatic agent.

  • Hair conditioning
  • Antistatic
  • pH adjuster
  • Flavouring
  • Conditioner
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 253 composition records across product categories including Personal care, Food and drug, Raw materials.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Glucosamine hydrochloride appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • EUEFSAEFSA statementStatement on the safety of glucosamine for patients receiving coumarin anticoagulants (EFSA NDA)
    • Statement on the safety of glucosamine for patients receiving coumarin anticoagulants (EFSA NDA)Source →
  • EUEFSAEFSA opinionOpinion of the safety of glucosamine hydrochloride from Aspergillus niger as food ingredient - Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA)
    • Opinion of the safety of glucosamine hydrochloride from Aspergillus niger as food ingredient - Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 253 composition records across product categories including Personal care, Food and drug, Raw materials. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, pH regulating agent.
    • EPA CPDat observed this chemical in 253 composition records across product categories including Personal care, Food and drug, Raw materials. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Softener and conditioner, pH regulating agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 4 active drug products and 4 total products.
    • FDA NDC lists this ingredient in 4 active drug products and 4 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Statement on the safety of glucosamine for patients receiving coumarin anticoagulants (EFSA NDA)

      2011 · EU EFSA listing · Read the source →

    • Opinion of the safety of glucosamine hydrochloride from Aspergillus niger as food ingredient - Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies (EFSA NDA)

      2009 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Glucosamine hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

drugoffice.gov.hk

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Glucosamine hydrochloride in a product composition. These are source records, not Greenveil catalog products.

Source records

253

Named organisations

6

Personal careFood and drugRaw materials

Typical roles

Hair conditioningAntistaticpH adjusterFlavouringConditioner
See products using Glucosamine hydrochloride →

Catalog

Found in these products

Cosmetic and personal-care products that list Glucosamine hydrochloride are shown first. Their ingredient lists include Glucosamine hydrochloride; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 27 →Find products without it →