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Vitamin D3

CAS 67-97-0 · 40/100 · High conf.

Also registered as 4 other CAS numbers

22350-41-0 · 2416217-93-9 · 8024-19-9 · 8050-67-7

Vitamin D3 chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Vitamin D3 in plain language

What it is

Also known as Cholecalciferol · Colecalciferol · Vitamin d assay system suitability · (3.BETA.,5Z,7E)-9,10-SECOCHOLESTA-5,7,10(19)-TRIEN-3-OL · (3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol · 7-DEHYDROCHOLESTEROL, activated

Show all 41 names

9,10-SECOCHOLESTA-5,7,10(19)-TRIEN-3-OL, (3.BETA.,5Z,7E)- · Ricketon · Vigantoletten · Vitamin d (cholecalciferol) · Vitamin D-3 · (3,beta., 5Z, 7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol · 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)- · 9,10-Secocholesta-5,7,10(19)-trien-3β-ol · 9,10-Secocholestra-5,7,10(19)-trien-3-ol, (3β,5Z,7E)- · Arachitol · Calciol · Cholecalciferol, Elaeis Guineensis (Palm) Oil · Cholecalciferolum · Colecalcipherol · D3-Vicotrat · D3-Vigantol · Delsterol · Delta-d · Deparal · Davitamon D · Ebivit · NEO Dohyfral D3 · Oleovitamin D3 · Provitina · Trivitan · Vigantol · Vi-de-3-hydrosol · Vigorsan · chloecalciferol (vitamin d3) · cholecalciferol (vitamin d3) manufacturing concentrate · DP-R206 component vitamin D3 · Fosamax plus d component cholecalciferol · Vitamin D3 (as cholecalciferol) · Ak R215 component colecalciferol · Colecalciferolum

What it does

Used in consumer products as a flavouring, a conditioner and an antimicrobial.

  • Flavouring
  • Conditioner
  • Antimicrobial
Is it a concern?
Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 164 composition records across product categories including Pesticides, Personal care, Construction.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Vitamin D3 appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • EUEFSAEFSA opinion5 entries
    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for chickens for fattening, turkeys, other poultry, pigs, piglets (suckling), calves for rearing, calves for fattening, bovines, ovines, equines, fish and other animal species or categories, based on a dossier submitted by DSM (EFSA FEEDAP)Source →
    • Safety of vitamin D3 addition to feedingstuffs for fish (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for all animal species or categories based on a dossier submitted by Lohmann Animal Health GmbH (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for pigs, piglets, bovines, ovines, calves, equines, chickens for fattening, turkeys, other poultry, fish and other animal species or categories, based on a dossier submitted by Fermenta Biotech Ltd (EFSA FEEDAP)Source →
    • Update of the tolerable upper intake level for vitamin D for infants (EFSA NDA)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 164 composition records across product categories including Pesticides, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Pharmaceutical, Biocide.
    • EPA CPDat observed this chemical in 164 composition records across product categories including Pesticides, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Pharmaceutical, Biocide.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 98 active drug products and 108 total products.
    • FDA NDC lists this ingredient in 98 active drug products and 108 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for chickens for fattening, turkeys, other poultry, pigs, piglets (suckling), calves for rearing, calves for fattening, bovines, ovines, equines, fish and other animal species or categories, based on a dossier submitted by DSM (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Safety of vitamin D3 addition to feedingstuffs for fish (EFSA FEEDAP)

      2017 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for all animal species or categories based on a dossier submitted by Lohmann Animal Health GmbH (EFSA FEEDAP)

      2014 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for pigs, piglets, bovines, ovines, calves, equines, chickens for fattening, turkeys, other poultry, fish and other animal species or categories, based on a dossier submitted by Fermenta Biotech Ltd (EFSA FEEDAP)

      2013 · EU EFSA listing · Read the source →

    • Update of the tolerable upper intake level for vitamin D for infants (EFSA NDA)

      2018 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Vitamin D3 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →
  • EPA Chemical and Products Database

    exposure · updated july 6, 2016

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2028-12-28

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (7)
Openfda substance

en.wikipedia.org

Openfda substance

en.wikipedia.org

Openfda substance

drugoffice.gov.hk

Openfda substance

adisinsight.springer.com

Openfda substance

lpi.oregonstate.edu

Openfda substance

clinicaltrials.gov

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Vitamin D3 in a product composition. These are source records, not Greenveil catalog products.

Source records

164

Named organisations

6

PesticidesPersonal careConstructionFood and drugRaw materialsPet and animal care

Typical roles

FlavouringConditionerAntimicrobial
See products using Vitamin D3 →

Catalog

Found in these products

Their ingredient lists include Vitamin D3; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Vitamin D3 in the catalog.