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Rebaudioside M

CAS 1220616-44-3 · 40/100 · High conf.

Rebaudioside M chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Rebaudioside M in plain language

What it is

Also known as Rebaudioside x · C56H90O33 · E960c · Gsgvxnmgmkbgqu-phesrwqrsa-n · HY-N6833 · MSK162904

Show all 10 names

Rebaudiosidem · Reb M · Reb X · UNII-FQA8XMC4XJ

What it does

We don't have a plain-language description for Rebaudioside M yet.

Is it a concern?
Moderate concern: no hazard classifications on record.

Why it's flagged

EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Rebaudioside M appears in these published regulatory listings.

  • EUEFSAEFSA opinionSafety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract (EFSA FAF)
    • Safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract (EFSA FAF)Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    • Safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: Rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract (EFSA FAF)

      2019 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Rebaudioside M yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Catalog

Found in these products

Their ingredient lists include Rebaudioside M; each product's own rating depends on its whole formula, so it is shown on the product page, not here.