beauty
cleaning
food
industrial

Biotin

CAS 22377-59-9 · 40/100 · High conf.

Also registered as 6 other CAS numbers

56846-45-8 · 3672-05-7 · 15720-24-8 · 22879-79-4 · 58073-87-3 · 58-85-5

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Biotin in plain language

What it is: Also known as D-biotin · D-(+)-biotin · Ritatin · Vitamin B7 · (+)-Biotin · Bioepiderm
Show all 21 names
Bios II · Biotin 1 % · Biotina · Biotine · Factor S · Factor S (vitamin) · Injacom H · MD-1003 · Vitamin Bw · biotin (vitamin h) · biotinum · cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid · cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid · coenzyme R · vitamin H
What it does: Used in cosmetics as a skin-conditioning agent and a hair conditioner.
Skin conditioning
Hair conditioning
Chelating agent
Flavouring
Conditioner
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 887 composition records across product categories including Food and drug, Personal care, Construction.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Biotin appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

EUEFSAEFSA opinion3 entries
- Scientific Opinion on the safety and efficacy of D-(+)-biotin as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of biotin as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)Source →
- Scientific Opinion on Dietary Reference Values for biotin (EFSA NDA)Source →
EUCosIngActiveBiotin is the organic compound that conforms to the formula
- Biotin is the organic compound that conforms to the formulaSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 887 composition records across product categories including Food and drug, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Active ingredient, Pharmaceutical.
- EPA CPDat observed this chemical in 887 composition records across product categories including Food and drug, Personal care, Construction. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Active ingredient, Pharmaceutical.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 98 active drug products and 105 total products.
- FDA NDC lists this ingredient in 98 active drug products and 105 total products.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety and efficacy of D-(+)-biotin as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of biotin as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on Dietary Reference Values for biotin (EFSA NDA)
  2014 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Biotin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated november 12, 2010
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

multiplesclerosisnewstoday.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Biotin in a product composition. These are source records, not Greenveil catalog products.

Source records

887

Named organisations

Food and drugPersonal careConstructionRaw materials

Typical roles

Skin conditioningHair conditioningChelating agentFlavouringConditioner

See products using Biotin →

Catalog

Found in these products

Their ingredient lists include Biotin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Biotin in the catalog.