beauty
cleaning
food
pharma

Poloxamer 124

CAS 691397-13-4

Also registered as 20 other CAS numbers

59392-44-8 · 62628-35-7 · 625857-39-8 · 625857-40-1 · 840541-58-4 · 846568-88-5 · 846568-89-6 · 1021692-93-2 · 1185748-62-2 · 1250831-01-6 · 1333506-01-6 · 1337563-97-9 · 1349100-02-2 · 1420378-22-8 · 1629855-99-7 · 1922925-59-4 · 1973382-53-4 · 1985655-31-9 · 2000229-53-6 · 2077070-17-6

Concern score

Not assessed — no hazard data yet.

Poloxamer 124 in plain language

What it is: Also known as Pluronic F 127 · Ethene oxide-propene oxide triblock copolymer · Ethylene glycol-propylene glycol copolymer triblock · Ethylene glycol-propylene glycol triblock copolymer · Ethylene oxide-propylene oxide triblock copolymer · Oxirane, 2-methyl-, polymer with oxirane, triblock
Show all 12 names
Oxirane, methyl-, polymer with oxirane, triblock · Pluronic L-44 · Pluronic L44 · Pluronic · Poloxamer 407 · poloxamer 188
What it does: Used in consumer products as an emulsifier, a surfactant and a thickener.
Emulsifier
Surfactant
Thickener
Antimicrobial
Is it a concern?: We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Poloxamer 124 appears in these published regulatory listings.

Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food

USFDAinactive ingredient database3 entries — 2 administration routes
- Route: ORAL; Dosage form: SUSPENSION; Potency: 0.09 mg/1mlSource →
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 4 mgSource →
- Route: TOPICAL; Dosage form: LOTION; Potency: 0.2 %w/wSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 494 composition records across product categories including Personal care, Cleaning products and household care, Home maintenance. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Viscosity modifier, Thickening agent.
- EPA CPDat observed this chemical in 494 composition records across product categories including Personal care, Cleaning products and household care, Home maintenance. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Viscosity modifier, Thickening agent.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as polymer.
- openFDA substance registry classifies this ingredient as polymer.Source →

Expert safety opinions

No expert opinion on file for Poloxamer 124. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
No EFSA opinion on file.

Evidence & sources

No graded research studies for Poloxamer 124 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

EPA Chemical and Products Database
exposure · updated September 2021
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →

Reference links (1)

Openfda substance

worldaccount.basf.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.